Cortexa research tool·genomics·signor

SIGNOR Get Interactions

Get causal signaling interactions for a protein or entity from the SIGNOR database. Returns upstream regulators and downstream targets with the type of effect (up/down-regulation), mechanism (phosphorylation, ubiquitination, transcriptional regulation, etc.), affected residue, and supporting literature. Use UniProt IDs (e.g., P04637 for TP53) or SIGNOR entity IDs.

Livelast probed 2026-05-01 01:00Z· 94msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 94ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "entity_id": {
      "description": "Entity identifier - typically a UniProt accession (e.g., 'P04637' for TP53, 'Q00987' for MDM2, 'P38398' for BRCA1). Can also be a SIGNOR complex/pathway ID.",
      "type": "string"
    },
    "limit": {
      "default": 50,
      "description": "Maximum number of interactions to return.",
      "type": "integer"
    },
    "organism": {
      "default": 9606,
      "description": "NCBI taxonomy ID. 9606 for human, 10090 for mouse.",
      "type": "integer"
    },
    "protein": {
      "description": "Gene symbol or protein name (alias for entity_id; prefer UniProt accession like P04637 for TP53)",
      "type": "string"
    }
  },
  "required": [],
  "type": "object"
}

Examples (1)

Default SIGNOR Get Interactions call

public-safeinput

{
  "limit": 3,
  "organism": 1
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_SIGNOR_get_interactions
Tool name: SIGNOR_get_interactions
Added: 2026-05-01 00:58Z
Tags: tooluniverse

SIGNOR Get Interactions

Livelast probed 2026-05-01 01:00Z· 94msCortexa

Schema

JSON Schema the agent (or your API call) must match.

{ "properties": { "entity_id": { "description": "Entity identifier - typically a UniProt accession (e.g., 'P04637' for TP53, 'Q00987' for MDM2, 'P38398' for BRCA1). Can also be a SIGNOR complex/pathway ID.", "type": "string" }, "limit": { "default": 50, "description": "Maximum number of interactions to return.", "type": "integer" }, "organism": { "default": 9606, "description": "NCBI taxonomy ID. 9606 for human, 10090 for mouse.", "type": "integer" }, "protein": { "description": "Gene symbol or protein name (alias for entity_id; prefer UniProt accession like P04637 for TP53)", "type": "string" } }, "required": [], "type": "object" }