STRING Functional Enrichment

Overview

Identify enriched biological functions, pathways, and processes for a protein set using STRING (Search Tool for Retrieval of Interacting Genes/Proteins) database. Performs statistical enrichment analysis against GO (Gene Ontology) terms, KEGG pathways, Reactome pathways, and other annotation databases. Returns significantly enriched terms with FDR-corrected p-values. Minimum 3-4 proteins required for meaningful statistical analysis. No API key required. Use for: discovering pathways enriched in protein network, identifying biological processes, finding shared functions among proteins, interpreting omics data (proteomics, interactomics), hypothesis generation.

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed

1d ago

Last success

1d ago

Last latency

106ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "category": {
      "default": "Process",
      "description": "Enrichment category: 'Process' (GO Biological Process), 'Component' (GO Cellular Component), 'Function' (GO Molecular Function), 'KEGG', 'Reactome', 'WikiPathways', 'COMPARTMENTS', 'TISSUES', 'DISEASES'",
      "enum": [
        "Process",
        "Component",
        "Function",
        "KEGG",
        "Reactome",
        "WikiPathways",
        "COMPARTMENTS",
        "TISSUES",
        "DISEASES"
      ],
      "type": "string"
    },
    "protein_ids": {
      "description": "List of protein identifiers (UniProt IDs, gene names, Ensembl IDs). Minimum 3 proteins recommended for meaningful enrichment.",
      "items": {
        "type": "string"
      },
      "minItems": 2,
      "type": "array"
    },
    "species": {
      "default": 9606,
      "description": "NCBI taxonomy ID (default: 9606 for human)",
      "type": "integer"
    }
  },
  "required": [
    "protein_ids"
  ],
  "type": "object"
}

Examples (1)

{
  "protein_ids": [],
  "species": 1
}

Identifiers

Catalog ID

tu_STRING_functional_enrichment

Tool name

STRING_functional_enrichment

Added

2026-04-30 22:47Z

Tags

tooluniverse