STRING Ppi Enrichment

Overview

Test if your protein set has more interactions than expected by chance (PPI = Protein-Protein Interaction enrichment). Compares observed interactions in your network to random expectation - significant enrichment suggests proteins work together functionally. Returns enrichment p-value and expected vs observed interaction counts. Useful for validating that your protein list forms a real functional module rather than random proteins. No API key required. Use for: validating protein complex predictions, testing if proteins form functional module, quality control for network analysis, distinguishing real complexes from random protein lists, assessing functional coherence.

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed

1d ago

Last success

1d ago

Last latency

113ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "confidence_score": {
      "default": 0.4,
      "description": "Minimum confidence score for counting interactions (0-1, default: 0.4)",
      "maximum": 1,
      "minimum": 0,
      "type": "number"
    },
    "protein_ids": {
      "description": "List of protein identifiers (UniProt IDs, gene names, Ensembl IDs). Minimum 3 proteins required.",
      "items": {
        "type": "string"
      },
      "minItems": 3,
      "type": "array"
    },
    "species": {
      "default": 9606,
      "description": "NCBI taxonomy ID (default: 9606 for human)",
      "type": "integer"
    }
  },
  "required": [
    "protein_ids"
  ],
  "type": "object"
}

Examples (1)

{
  "confidence_score": 1,
  "protein_ids": [],
  "species": 1
}

Identifiers

Catalog ID

tu_STRING_ppi_enrichment

Tool name

STRING_ppi_enrichment

Added

2026-04-30 22:47Z

Tags

tooluniverse