SYNERGxDB Search Combos

Overview

Search drug combination synergy scores in SYNERGxDB. Returns synergy metrics (Bliss, Loewe, HSA, ZIP) for drug pairs across cancer cell lines. Filter by drug IDs, cell line/tissue, and dataset. The database integrates 22,507 unique drug combinations from 9 major studies (NCI-ALMANAC, MERCK, MIT-MELANOMA, VISAGE, DECREASE, YALE-TNBC, YALE-PDAC, STANFORD, CLOUD). Positive ZIP scores indicate synergy. Use list_drugs first to find drug IDs. NOTE: SYNERGxDB covers pairwise in vitro cytotoxicity screening; standard-of-care clinical regimens (FOLFOX, FOLFIRI, CAPOX, R-CHOP) and most targeted therapies/biologics (BRAF/MEK/KRAS inhibitors, immune checkpoint inhibitors, monoclonal antibodies) are not represented.

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed

1d ago

Last success

1d ago

Last latency

237ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "dataset": {
      "description": "Dataset source ID (integer) or name (string). Examples: 2 or 'NCI-ALMANAC', 1 or 'MERCK', 10 or 'VISAGE', 7 or 'MIT-MELANOMA'. Use SYNERGxDB_list_datasets to see all available datasets and their IDs.",
      "type": [
        "integer",
        "string",
        "null"
      ]
    },
    "drug_id_1": {
      "description": "SYNERGxDB drug ID for drug A. Use SYNERGxDB_list_drugs to find IDs. Examples: 11 (Bortezomib), 48 (Imatinib), 52 (Lapatinib). Alternatively, use drug_name_1 for automatic ID lookup.",
      "type": [
        "integer",
        "null"
      ]
    },
    "drug_id_2": {
      "description": "SYNERGxDB drug ID for drug B. Examples: 97 (Topotecan), 34 (Erlotinib), 24 (Dasatinib). Alternatively, use drug_name_2 for automatic ID lookup.",
      "type": [
        "integer",
        "null"
      ]
    },
    "drug_name_1": {
      "description": "Drug name for drug A — triggers automatic SYNERGxDB ID lookup (e.g., 'gemcitabine', 'imatinib', 'paclitaxel'). Aliases: drug1. Use instead of drug_id_1 when you don't know the integer ID.",
      "type": [
        "string",
        "null"
      ]
    },
    "drug_name_2": {
      "description": "Drug name for drug B — triggers automatic SYNERGxDB ID lookup (e.g., 'erlotinib', 'topotecan', 'oxaliplatin'). Aliases: drug2. Use instead of drug_id_2 when you don't know the integer ID.",
      "type": [
        "string",
        "null"
      ]
    },
    "operation": {
      "description": "Operation type",
      "enum": [
        "search_combos"
      ],
      "type": "string"
    },
    "page": {
      "default": 1,
      "description": "Page number for paginated results (default: 1)",
      "minimum": 1,
      "type": "integer"
    },
    "per_page": {
      "default": 20,
      "description": "Results per page (default: 20, max: 500)",
      "maximum": 500,
      "minimum": 1,
      "type": "integer"
    },
    "sample": {
      "description": "Cell line ID (integer as string) or tissue name. Valid tissue names: 'colorectal' (NOT 'colon'), 'blood', 'breast', 'lung', 'ovary', 'skin', 'CNS', 'prostate', 'kidney', 'pancreas', 'gastric', 'melanoma'. Use SYNERGxDB_list_cell_lines to find valid values. Aliases: tissue_name, tissue. Common alias 'colon' is auto-mapped to 'colorectal'.",
      "type": [
        "string",
        "null"
      ]
    }
  },
  "required": [],
  "type": "object"
}

Examples (1)

{
  "page": 1,
  "per_page": 1
}

Identifiers

Catalog ID

tu_SYNERGxDB_search_combos

Tool name

SYNERGxDB_search_combos

Added

2026-05-01 00:58Z

Tags

tooluniverse