Cortexa research tool·genomics·spliceai

SpliceAI Predict Splice

Predict splice-altering effects using SpliceAI deep learning model. Returns delta scores for acceptor gain (DS_AG), acceptor loss (DS_AL), donor gain (DS_DG), donor loss (DS_DL). Scores ≥0.2 suggest splice impact, ≥0.5 moderate, ≥0.8 high pathogenicity. Critical for intronic/exonic variant interpretation.

Livelast probed 2026-04-30 23:07Z· 105msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 105ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "distance": {
      "default": 50,
      "description": "Distance parameter for model (default: 50). Larger values capture more distal effects.",
      "type": "integer"
    },
    "genome": {
      "default": "38",
      "description": "Genome build: 37 (GRCh37/hg19) or 38 (GRCh38/hg38). Default: 38",
      "enum": [
        "37",
        "38"
      ],
      "type": "string"
    },
    "mask": {
      "default": false,
      "description": "Use masked scores (recommended for variant interpretation). Raw scores better for alternative splicing analysis.",
      "type": "boolean"
    },
    "variant": {
      "description": "Variant in chr-pos-ref-alt format (e.g., chr8-140300616-T-G) or colon-separated",
      "type": "string"
    }
  },
  "required": [
    "variant"
  ],
  "type": "object"
}

Examples (1)

Default SpliceAI Predict Splice call

public-safeinput

{
  "distance": 1,
  "mask": false,
  "variant": ""
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_SpliceAI_predict_splice
Tool name: SpliceAI_predict_splice
Added: 2026-04-30 22:47Z
Tags: tooluniverse

SpliceAI Predict Splice

Livelast probed 2026-04-30 23:07Z· 105msCortexa

Schema

JSON Schema the agent (or your API call) must match.

{ "properties": { "distance": { "default": 50, "description": "Distance parameter for model (default: 50). Larger values capture more distal effects.", "type": "integer" }, "genome": { "default": "38", "description": "Genome build: 37 (GRCh37/hg19) or 38 (GRCh38/hg38). Default: 38", "enum": [ "37", "38" ], "type": "string" }, "mask": { "default": false, "description": "Use masked scores (recommended for variant interpretation). Raw scores better for alternative splicing analysis.", "type": "boolean" }, "variant": { "description": "Variant in chr-pos-ref-alt format (e.g., chr8-140300616-T-G) or colon-separated", "type": "string" } }, "required": [ "variant" ], "type": "object" }