Cortexa research tool·genomics·timer

TIMER2 Immune Estimation

Estimate immune cell abundance in TCGA cancer samples using TIMER-equivalent marker gene expression from cBioPortal. Returns infiltration proxies for 6 immune cell types (B cells, CD4+ T cells, CD8+ T cells, neutrophils, macrophages, dendritic cells) using canonical marker genes (CD19, CD4, CD8A, FCGR3B, CD68, ITGAX). Note: TIMER2.0/3.0 REST API is no longer public; this tool uses cBioPortal TCGA data as a proxy.

Livelast probed 2026-04-30 23:07Z· 98msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 98ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "cancer": {
      "description": "TCGA cancer type abbreviation (e.g., 'BRCA', 'LUAD', 'COAD', 'SKCM', 'GBM')",
      "type": "string"
    },
    "gene": {
      "description": "Optional gene symbol to correlate with immune infiltration (e.g., 'CD8A', 'PDCD1')",
      "type": [
        "string",
        "null"
      ]
    },
    "operation": {
      "description": "Operation type",
      "enum": [
        "immune_estimation"
      ],
      "type": "string"
    }
  },
  "required": [
    "operation",
    "cancer"
  ],
  "type": "object"
}

Examples (1)

Default TIMER2 Immune Estimation call

public-safeinput

{
  "cancer": "",
  "operation": ""
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_TIMER2_immune_estimation
Tool name: TIMER2_immune_estimation
Added: 2026-04-30 22:47Z
Tags: tooluniverse

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