Cortexa research tool·chemistry·zinc

ZINC Search By Properties

Filter ZINC compounds by molecular properties (Lipinski Rule of Five, Veber rules). Specify ranges for molecular weight, LogP, hydrogen bond donors/acceptors, and rotatable bonds. Optionally restrict to a purchasability tier. Useful for finding drug-like compounds: Lipinski (MW<500, LogP<5, HBD<5, HBA<10), fragment-like (MW<250, LogP<3), or lead-like (MW 250-350, LogP 1-3).

Livelast probed 2026-04-30 23:07Z· 99msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 99ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "count": {
      "default": 20,
      "description": "Maximum number of results (default: 20, max: 100)",
      "maximum": 100,
      "minimum": 1,
      "type": "integer"
    },
    "hba_max": {
      "description": "Maximum hydrogen bond acceptors (e.g., 10 for Lipinski)",
      "type": [
        "integer",
        "null"
      ]
    },
    "hbd_max": {
      "description": "Maximum hydrogen bond donors (e.g., 5 for Lipinski)",
      "type": [
        "integer",
        "null"
      ]
    },
    "logp_max": {
      "description": "Maximum LogP (e.g., 5 for Lipinski rule, 3 for lead-like)",
      "type": [
        "number",
        "null"
      ]
    },
    "logp_min": {
      "description": "Minimum LogP (e.g., -1 for hydrophilic compounds)",
      "type": [
        "number",
        "null"
      ]
    },
    "mwt_max": {
      "description": "Maximum molecular weight in Da (e.g., 500 for Lipinski, 250 for fragments)",
      "type": [
        "number",
        "null"
      ]
    },
    "mwt_min": {
      "description": "Minimum molecular weight in Da (e.g., 150 for fragments, 250 for leads)",
      "type": [
        "number",
        "null"
      ]
    },
    "operation": {
      "description": "Operation type",
      "enum": [
        "search_by_properties"
      ],
      "type": "string"
    },
    "purchasability": {
      "description": "Restrict to a purchasability tier",
      "enum": [
        "in-stock",
        "for-sale",
        "on-demand",
        "agent",
        null
      ],
      "type": [
        "string",
        "null"
      ]
    },
    "rb_max": {
      "description": "Maximum rotatable bonds (e.g., 10 for Veber rule)",
      "type": [
        "integer",
        "null"
      ]
    }
  },
  "required": [
    "operation"
  ],
  "type": "object"
}

Examples (1)

Default ZINC Search By Properties call

public-safeinput

{
  "count": 1,
  "operation": ""
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_ZINC_search_by_properties
Tool name: ZINC_search_by_properties
Added: 2026-04-30 22:47Z
Tags: tooluniverse

ZINC Search By Properties

Livelast probed 2026-04-30 23:07Z· 99msCortexa

Schema

JSON Schema the agent (or your API call) must match.

{ "properties": { "count": { "default": 20, "description": "Maximum number of results (default: 20, max: 100)", "maximum": 100, "minimum": 1, "type": "integer" }, "hba_max": { "description": "Maximum hydrogen bond acceptors (e.g., 10 for Lipinski)", "type": [ "integer", "null" ] }, "hbd_max": { "description": "Maximum hydrogen bond donors (e.g., 5 for Lipinski)", "type": [ "integer", "null" ] }, "logp_max": { "description": "Maximum LogP (e.g., 5 for Lipinski rule, 3 for lead-like)", "type": [ "number", "null" ] }, "logp_min": { "description": "Minimum LogP (e.g., -1 for hydrophilic compounds)", "type": [ "number", "null" ] }, "mwt_max": { "description": "Maximum molecular weight in Da (e.g., 500 for Lipinski, 250 for fragments)", "type": [ "number", "null" ] }, "mwt_min": { "description": "Minimum molecular weight in Da (e.g., 150 for fragments, 250 for leads)", "type": [ "number", "null" ] }, "operation": { "description": "Operation type", "enum": [ "search_by_properties" ], "type": "string" }, "purchasability": { "description": "Restrict to a purchasability tier", "enum": [ "in-stock", "for-sale", "on-demand", "agent", null ], "type": [ "string", "null" ] }, "rb_max": { "description": "Maximum rotatable bonds (e.g., 10 for Veber rule)", "type": [ "integer", "null" ] } }, "required": [ "operation" ], "type": "object" }