Cortexa research tool·chemistry·civic

Civic Search Evidence Items

Search for evidence items in CIViC database. Evidence items are curated statements linking variants or molecular profiles to clinical outcomes, therapies, or disease states. Returns evidence with disease, therapies, significance, direction, and citation. Filter by therapy name (e.g., 'imatinib'), disease name (e.g., 'leukemia'), or molecular profile name (e.g., 'BRAF V600E').

Livelast probed 2026-04-30 23:07Z· 499msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 499ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "disease": {
      "description": "Filter by disease name (e.g., 'leukemia', 'melanoma', 'lung cancer'). Alias: disease_name. Note: CIViC uses specific disease names (e.g., 'Lung Non-small Cell Carcinoma', not 'NSCLC'); try partial names or multiple searches if results are empty.",
      "type": "string"
    },
    "disease_name": {
      "description": "Alias for disease. Filter by disease name.",
      "type": "string"
    },
    "evidence_type": {
      "description": "Filter by evidence type. Values: PREDICTIVE (drug response), DIAGNOSTIC (disease diagnosis), PROGNOSTIC (patient outcomes), PREDISPOSING (disease risk), ONCOGENIC (variant pathogenicity), FUNCTIONAL (molecular function).",
      "type": [
        "string",
        "null"
      ]
    },
    "limit": {
      "default": 20,
      "description": "Maximum number of evidence items to return (default: 20, recommended max: 100)",
      "type": "integer"
    },
    "molecular_profile": {
      "description": "Filter by molecular profile name (e.g., 'BRAF V600E', 'EGFR T790M', 'KRAS G12C'). Uses substring matching — 'FLT3 ITD' will also match 'FLT3 ITD AND FLT3 D835Y'. For gene fusions, CIViC uses double-colon notation: 'GENE::PARTNER Fusion' (e.g., 'FGFR2::BICC1 Fusion', 'ALK::EML4 Fusion'). Use civic_search_molecular_profiles to discover exact profile names.",
      "type": "string"
    },
    "status": {
      "description": "Filter by curation status. Default: ACCEPTED (peer-reviewed). Options: ACCEPTED, SUBMITTED, REJECTED, ALL (returns all statuses combined).",
      "type": [
        "string",
        "null"
      ]
    },
    "therapy": {
      "description": "Filter by therapy/drug name (e.g., 'imatinib', 'pembrolizumab'). Alias: therapy_name. Note: matches any evidence item where the therapy appears, including combination regimens — results may include multi-drug combinations.",
      "type": "string"
    },
    "therapy_name": {
      "description": "Alias for therapy. Filter by therapy/drug name.",
      "type": "string"
    }
  },
  "required": [],
  "type": "object"
}

Examples (1)

Default Civic Search Evidence Items call

public-safeinput

{
  "disease": "type 2 diabetes",
  "disease_name": "type 2 diabetes",
  "limit": 3
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_civic_search_evidence_items
Tool name: civic_search_evidence_items
Added: 2026-04-30 22:47Z
Tags: tooluniverse

Civic Search Evidence Items

Livelast probed 2026-04-30 23:07Z· 499msCortexa

Schema

JSON Schema the agent (or your API call) must match.

{ "properties": { "disease": { "description": "Filter by disease name (e.g., 'leukemia', 'melanoma', 'lung cancer'). Alias: disease_name. Note: CIViC uses specific disease names (e.g., 'Lung Non-small Cell Carcinoma', not 'NSCLC'); try partial names or multiple searches if results are empty.", "type": "string" }, "disease_name": { "description": "Alias for disease. Filter by disease name.", "type": "string" }, "evidence_type": { "description": "Filter by evidence type. Values: PREDICTIVE (drug response), DIAGNOSTIC (disease diagnosis), PROGNOSTIC (patient outcomes), PREDISPOSING (disease risk), ONCOGENIC (variant pathogenicity), FUNCTIONAL (molecular function).", "type": [ "string", "null" ] }, "limit": { "default": 20, "description": "Maximum number of evidence items to return (default: 20, recommended max: 100)", "type": "integer" }, "molecular_profile": { "description": "Filter by molecular profile name (e.g., 'BRAF V600E', 'EGFR T790M', 'KRAS G12C'). Uses substring matching — 'FLT3 ITD' will also match 'FLT3 ITD AND FLT3 D835Y'. For gene fusions, CIViC uses double-colon notation: 'GENE::PARTNER Fusion' (e.g., 'FGFR2::BICC1 Fusion', 'ALK::EML4 Fusion'). Use civic_search_molecular_profiles to discover exact profile names.", "type": "string" }, "status": { "description": "Filter by curation status. Default: ACCEPTED (peer-reviewed). Options: ACCEPTED, SUBMITTED, REJECTED, ALL (returns all statuses combined).", "type": [ "string", "null" ] }, "therapy": { "description": "Filter by therapy/drug name (e.g., 'imatinib', 'pembrolizumab'). Alias: therapy_name. Note: matches any evidence item where the therapy appears, including combination regimens — results may include multi-drug combinations.", "type": "string" }, "therapy_name": { "description": "Alias for therapy. Filter by therapy/drug name.", "type": "string" } }, "required": [], "type": "object" }