Cortexa research tool·genomics·civic

Civic Search Variants

Search for variants in CIViC database. Returns a list of variants with their IDs and names. Use 'query' to search by variant name (e.g., 'V600E'), or 'gene'/'gene_name' to get all variants for a specific gene (e.g., 'EGFR'). To find a specific variant in a gene, combine gene_name + variant_name (e.g., gene_name='EGFR', variant_name='L858R'). Note: CIViC stores variants without gene prefix — do not combine gene and variant in a single string.

Livelast probed 2026-04-30 23:07Z· 347msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 347ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "gene": {
      "description": "Gene symbol to filter variants by (e.g., 'EGFR', 'BRAF', 'KRAS'). Returns all variants for that gene.",
      "type": "string"
    },
    "gene_name": {
      "description": "Alias for gene. Gene symbol (e.g., 'TP53', 'BRCA1').",
      "type": "string"
    },
    "limit": {
      "default": 20,
      "description": "Maximum number of variants to return (default: 20, recommended max: 100)",
      "type": "integer"
    },
    "query": {
      "description": "Variant name to search for (e.g., \"T790M\", \"V600E\", \"exon 19 deletion\"). Returns name-matching variants.",
      "type": "string"
    },
    "variant_name": {
      "description": "Specific variant name to filter within a gene (e.g., 'L858R', 'V600E', 'T790M'). Use together with gene_name — CIViC stores variants without the gene prefix (use 'L858R' not 'EGFR L858R').",
      "type": "string"
    }
  },
  "required": [],
  "type": "object"
}

Examples (1)

Default Civic Search Variants call

public-safeinput

{
  "gene": "BRCA1",
  "gene_name": "BRCA1",
  "limit": 3,
  "query": "BRCA1"
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_civic_search_variants
Tool name: civic_search_variants
Added: 2026-04-30 22:47Z
Tags: tooluniverse

Civic Search Variants

Livelast probed 2026-04-30 23:07Z· 347msCortexa

Schema

JSON Schema the agent (or your API call) must match.

{ "properties": { "gene": { "description": "Gene symbol to filter variants by (e.g., 'EGFR', 'BRAF', 'KRAS'). Returns all variants for that gene.", "type": "string" }, "gene_name": { "description": "Alias for gene. Gene symbol (e.g., 'TP53', 'BRCA1').", "type": "string" }, "limit": { "default": 20, "description": "Maximum number of variants to return (default: 20, recommended max: 100)", "type": "integer" }, "query": { "description": "Variant name to search for (e.g., \"T790M\", \"V600E\", \"exon 19 deletion\"). Returns name-matching variants.", "type": "string" }, "variant_name": { "description": "Specific variant name to filter within a gene (e.g., 'L858R', 'V600E', 'T790M'). Use together with gene_name — CIViC stores variants without the gene prefix (use 'L858R' not 'EGFR L858R').", "type": "string" } }, "required": [], "type": "object" }