GProfiler Enrichment

Overview

Perform functional enrichment analysis on a gene list using g:Profiler (g:GOSt) from the University of Tartu. Identifies statistically overrepresented biological functions, pathways, and phenotypes in your gene list. Supports multiple data sources: Gene Ontology (GO:BP, GO:MF, GO:CC), KEGG pathways, Reactome, WikiPathways, Human Phenotype Ontology (HP), miRNA targets (MIRNA), CORUM protein complexes, and Transcription Factor targets (TF). Returns enriched terms with p-values (g:SCS multiple testing correction), term sizes, intersection genes, precision, and recall. Input is a list of gene symbols (e.g., ['TP53', 'BRCA1', 'EGFR', 'KRAS', 'PTEN']). Supports 500+ organisms (use NCBI taxonomy prefix, e.g., 'hsapiens', 'mmusculus', 'dmelanogaster').

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed

1d ago

Last success

1d ago

Last latency

104ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "gene_list": {
      "description": "Comma-separated list of gene symbols. Examples: 'TP53,BRCA1,EGFR,KRAS,PTEN' or 'Trp53,Brca1,Egfr' (mouse).",
      "type": "string"
    },
    "organism": {
      "description": "Organism identifier. Default: 'hsapiens'. Examples: 'hsapiens' (human), 'mmusculus' (mouse), 'dmelanogaster' (fly), 'scerevisiae' (yeast), 'drerio' (zebrafish).",
      "type": "string"
    },
    "sources": {
      "description": "Comma-separated data sources to query. Default: 'GO:BP,GO:MF,GO:CC,KEGG,REAC,WP,HP'. Options: GO:BP, GO:MF, GO:CC, KEGG, REAC, WP, MIRNA, HPA, CORUM, HP, TF.",
      "type": "string"
    }
  },
  "required": [
    "gene_list"
  ],
  "type": "object"
}

Examples (1)

{
  "gene_list": "BRCA1"
}

Identifiers

Catalog ID

tu_gProfiler_enrichment

Tool name

gProfiler_enrichment

Added

2026-04-30 22:47Z

Tags

tooluniverse