Cortexa research tool·genomics·gnomad

Gnomad Get Gene Constraints

Get gene constraint metrics from gnomAD for a gene symbol (GRCh38). Returns constraint fields under `exac_constraint` and `gnomad_constraint` (e.g., pLI, oe_lof/oe_mis/oe_syn, exp/obs counts).

Livelast probed 2026-05-01 01:00Z· 203msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 203ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "gene_symbol": {
      "description": "Gene symbol (e.g., 'BRCA1', 'TP53')",
      "type": "string"
    },
    "reference_genome": {
      "default": "GRCh38",
      "description": "Reference genome.",
      "enum": [
        "GRCh37",
        "GRCh38"
      ],
      "type": "string"
    }
  },
  "required": [
    "gene_symbol"
  ],
  "type": "object"
}

Examples (1)

Default Gnomad Get Gene Constraints call

public-safeinput

{
  "gene_symbol": "BRCA1"
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_gnomad_get_gene_constraints
Tool name: gnomad_get_gene_constraints
Added: 2026-05-01 00:58Z
Tags: tooluniverse

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